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【medical-news】乳腺癌转移新靶点--Brk！
ScienceDaily (Aug. 29, 2009) — Dr. Amanda Harvey and colleagues at Brunel University have demonstrated that the protein Brk plays a role in breast cancer progression and dissemination. Their report can be found in the September 2009 issue of the American Journal of Pathology.
Breast cancer metastasis causes nearly 90% of the lethality among breast cancer patients. Non-metastatic breast cancer cells rely on interactions with other cells and the extracellular matrix to survive. Metastatic breast cancer cells must survive in the absence of these interactions.
Harvey et al hypothesized that Brk, a tyrosine kinase expressed predominantly in breast tumors compared with normal breast tissue, plays a role in breast cancer progression by promoting anchorage independence. Indeed, high-grade tumors from human breast cancer patients expressed elevated levels of Brk when compared with lower grade tumors. Inhibiting Brk expression resulted in cell death in the absence of cell-cell and cell-matrix interactions, and tumor cells with increased levels of Brk expression survived without these interactions. These data therefore support a role for Brk in breast cancer progression and dissemination.
Dr. Harvey and colleagues suggest "that Brk plays a role in protecting breast cancer cells from detachment-induced cell death. Therefore, Brk expression in carcinomas may confer a survival advantage on metastasizing tumor cells. … [Future studies will examine] whether this function is manifest in other Brk-positive tumor cells from tissues other than the breast, such as the colon and prostate."
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Journal reference:
Harvey AJ, Pennington CJ, Porter S, Burmi RS, Edwards DR, Court W, Eccles SA, Crompton MR. Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage. American Journal of Pathology, 2009, 175: 1226-1234
Adapted from materials provided by American Journal of Pathology, via EurekAlert!, a service of AAAS.
http://www.sciencedaily.com/releases/2009/08/090826110116.htm 本人认领这篇文章的翻译；若48小时内没有提交请其他战友自由认领。 New Target For Treating Breast Cancer Metastasis
治疗乳腺癌转移的新靶点
ScienceDaily (Aug. 29, 2009) — Dr. Amanda Harvey and colleagues at Brunel University have demonstrated that the protein Brk plays a role in breast cancer progression and dissemination. Their report can be found in the September 2009 issue of the American Journal of Pathology.
今日科学（2009.8.29）报道，Brunel大学Amanda Harvey博士及其同事证实了Brk蛋白在乳腺癌进展和扩散中发挥重要作用。该研究发表于2009年9月出版的《美国病理学杂志》上。
Breast cancer metastasis causes nearly 90% of the lethality among breast cancer patients. Non-metastatic breast cancer cells rely on interactions with other cells and the extracellular matrix to survive. Metastatic breast cancer cells must survive in the absence of these interactions.
乳腺癌转移可导致近90%乳腺癌病人死亡。非转移性乳腺癌细胞依靠与其他细胞和细胞外基质相互作用而生存。在缺乏这些相互作用时转移性乳腺癌细胞应能生存。
Harvey et al hypothesized that Brk, a tyrosine kinase expressed predominantly in breast tumors compared with normal breast tissue, plays a role in breast cancer progression by promoting anchorage independence. Indeed, high-grade tumors from human breast cancer patients expressed elevated levels of Brk when compared with lower grade tumors. Inhibiting Brk expression resulted in cell death in the absence of cell-cell and cell-matrix interactions, and tumor cells with increased levels of Brk expression survived without these interactions. These data therefore support a role for Brk in breast cancer progression and dissemination.
Harvey等推测，与正常乳腺组织相比，Brk，一种主要表达于乳腺肿瘤的酪氨酸激酶，通过促进锚着非依赖性在乳腺癌进展中起着重要作用。的确，与低级别肿瘤比较，高级别肿瘤表达较高水平的Brk。在缺乏细胞-细胞和细胞-间质相互作用的情况下，抑制Brk表达可导致细胞死亡，Brk表达水平高的肿瘤细胞在无这些作用时可存活。因此这些资料支持Brk在乳腺癌进展和扩散中的作用。
Dr. Harvey and colleagues suggest "that Brk plays a role in protecting breast cancer cells from detachment-induced cell death. Therefore, Brk expression in carcinomas may confer a survival advantage on metastasizing tumor cells. … [Future studies will examine] whether this function is manifest in other Brk-positive tumor cells from tissues other than the breast, such as the colon and prostate."
Harvey博士和同事建议“Brk在保护乳腺癌细胞免于分离诱导的细胞死亡中担负重要作用。因此，癌组织中Brk表达对转移性肿瘤细胞可提供一个生存优势…【将进行进一步研究】这种功能是否在其他Brk阳性肿瘤细胞中，除了乳腺，还有结肠和前列腺中表现。 治疗乳腺癌转移的新靶点
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作者:admin@医学,生命科学 2010-10-03 17:11
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