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【文摘发布】区域淋巴结外侵对手术切除非小细
Chest. 2007 Apr;131(4):993-9.
Significance of Extranodal Extension of Regional Lymph Nodes in Surgically Resected Non-small Cell Lung Cancer.
STUDY OBJECTIVES: Regional lymph node (LN) involvement affects the prognosis of patients with surgically resected non-small cell lung cancer (NSCLC). The significance of extranodal extension in these groups of patients was prospectively studied to determine its clinicopathologic relationships and its influence on patient survival. METHODS: A total of 199 NSCLC patients who were proved to have regional LN involvement after resection were included. Histologic examinations including tumor cell type, grade of differentiation, vascular invasion, regional LN metastasis emphasizing the number and station of LN involvement, the presence or absence of extranodal extension, and the immunohistochemistry of p53 expression were obtained. The relationships between extranodal extension and histologic type, grade of differentiation, vascular invasion, tumor size, pathologic stage, p53 expression, or patient survival were analyzed. RESULTS: Extranodal extension was significantly higher in women, adenocarcinoma, advanced stage, tumors with vascular invasion, or p53 overexpression. The total number and positive rate of resected LNs with extranodal extension were significantly correlated with advanced stage, tumors with vascular invasion, or p53 overexpression. By multivariate analysis of survival, the presence or total number of LNs with extranodal extension, tumor stage, and p53 expression were significant prognostic factors. The 5-year survival rate of stage IIIA patients without extranodal extension (30.4%) was significantly better than that of stage II patients with extranodal extension (16.8%). No survival difference between extranodal positive stage II and IIIA patients was noted. CONCLUSIONS: Extranodal extension of regional LNs is an important prognostic factor in patients with surgically resected NSCLC. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Significance of Extranodal Extension of Regional Lymph Nodes in Surgically Resected Non-small Cell Lung Cancer.
区域淋巴结外侵对手术切除非小细胞肺癌的意义
Chest. 2007 Apr;131(4):993-9.
STUDY OBJECTIVES: Regional lymph node (LN) involvement affects the prognosis of patients with surgically resected non-small cell lung cancer (NSCLC). The significance of extranodal extension in these groups of patients was prospectively studied to determine its clinicopathologic relationships and its influence on patient survival.
目的：区域淋巴结（LN）情况影响手术切除非小细胞肺癌(NSCLC)患者的预后。对这些病人淋巴结外侵犯的重要性进行了前瞻性的研究，来判定它与临床病理特征的关系和对病人的存活率的影响。
METHODS: A total of 199 NSCLC patients who were proved to have regional LN involvement after resection were included. Histologic examinations including tumor cell type, grade of differentiation, vascular invasion, regional LN metastasis emphasizing the number and station of LN involvement, the presence or absence of extranodal extension, and the immunohistochemistry of p53 expression were obtained. The relationships between extranodal extension and histologic type, grade of differentiation, vascular invasion, tumor size, pathologic stage, p53 expression, or patient survival were analyzed.
方法：实验包括199例手术切除的被证实的区域淋巴结转移的非小细胞肺癌患者。组织细胞学检查包括肿瘤细胞类型，分化程度，血管受侵，区域淋巴结转移（重点在于转移的数量和累及的站数），是否伴有淋巴结外侵和p53的免疫组化表达。分析了淋巴结外侵与组织类型，分化程度，血管受侵，肿瘤大小，病理分期，p53的表达和病人的存活率之间的关系。
RESULTS: Extranodal extension was significantly higher in women, adenocarcinoma, advanced stage, tumors with vascular invasion, or p53 overexpression. The total number and positive rate of resected LNs with extranodal extension were significantly correlated with advanced stage, tumors with vascular invasion, or p53 overexpression. By multivariate analysis of survival, the presence or total number of LNs with extranodal extension, tumor stage, and p53 expression were significant prognostic factors. The 5-year survival rate of stage IIIA patients without extranodal extension (30.4%) was significantly better than that of stage II patients with extranodal extension (16.8%). No survival difference between extranodal positive stage II and IIIA patients was noted.
结果：在女性，腺癌，晚期，肿瘤侵犯血管，p53的过度表达者淋巴结外侵犯明显增高。切除的伴有淋巴结外侵犯的淋巴结的数量和阳性率与晚期、肿瘤侵犯血管、p53的过度表达呈显著相关。对生存率多因素分析显示：是否存在区域淋巴结外侵及其数量，肿瘤分期，p53的表达是重要的预后因子。无外侵的IIIA期患者的五年存活率是30.4%，明显高于伴有淋巴结外侵的II期患者（16.8%）。据统计伴有淋巴结外侵的II期和IIIA期病人的存活率之间无差异。
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作者:admin@医学,生命科学 2010-10-03 05:11
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