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【medical-news】减少剖腹产出血:麦角新碱加缩宫

Ergometrine Added to Oxytocin Does Not Reduce Blood Loss at Caesarean Delivery

NEW YORK (Reuters Health) May 02 - Co-administration of oxytocin and ergometrine is no better than oxytocin alone for decreasing blood loss during emergency caesarean delivery, according to Canadian researchers.

Dr. M. Balki and colleagues at Mount Sinai Hospital in Toronto compared the two drug regimens in 48 healthy women undergoing caesarean deliveries for labor arrest. They were randomly assigned in a double-blind fashion to receive either ergometrine maleate 0.25 mg plus oxytocin 20 IU or oxytocin 20 IU alone, given in part as a bolus immediately after delivery and then in a continuous infusion for 6 hours.

According to the report in the April issue of BJOG: An International Journal of Obstetrics and Gynaecology, uterine contractility was more effective with combined treatment. Nevertheless, estimated blood loss did not differ significantly between groups (1218 mL in the oxytocin-ergometrine group vs 1299 mL in the oxytocin-only group).

However, nausea and vomiting were significantly more prevalent among women treated with oxytocin and ergometrine.

Given the drug combination's lack of benefit in their study, the authors said, their results "have stimulated discussions in our research group regarding the importance of optimizing obstetric surgical techniques to reduce operative blood loss."

BJOG 2008;115:579-584.

http://www.medscape.com/viewarticle/573971

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作者:admin@医学,生命科学    2010-12-09 05:11
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