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【drug-news】酶可能是疟原虫最薄弱的环节
04 May 2008
NewScientist.com news service
Malaria parasites kill a million people a year, by infecting their red blood cells and gobbling up the haemoglobin proteins that transport oxygen in the blood.
But the "haem" portion of haemoglobin is toxic and, to avoid destruction, the Plasmodium parasite turns it into a non-toxic crystal called haemozoin.
Several existing malaria drugs work by binding to haem and stopping its transformation. However, understanding the process better could lead to the development of desperately needed new drugs for malaria.
Now Dewal Jani and his colleagues at Virginia Tech in Blacksburg have identified the key enzyme used by the parasite - called HDP. Mass screening has also identified several chemicals that might inhibit HDP, which is conserved across all Plasmodium species they tested
http://www.newscientist.com/article/mg19826544.800-enzyme-could-be-malarias-weakest-link.html?DCMP=ILC-hmts&nsref=news2_head_mg19826544.800
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酶可能是疟原虫最薄弱的环节
（《新科学家》网站2008年5月5日报道）
疟原虫通过感染人体内的红血球以及吞噬血中输氧的血红蛋白，每年杀死的人数达到一百万。
但是血红蛋白中“血红素”部分是有毒的，于是，为避免殃及自身，疟原虫念起了紧箍咒，让血红素变成了无毒的称之为疟原虫色素的晶体。
几种现有的抗疟药通过与血红素结合而阻止血红素变化来发挥作用。不过，更好地理解这一过程可以引导我们开发急需的抗疟新药。
目前，位于布莱克斯堡的弗尼尼亚工学院的铥瓦尔· 杰尼与其同事已经证实了疟原虫所用的叫做HDP的关键的酶，并且所有种类疟原虫体内都贮存有HDP，而大量的筛选工作证明了几种化学品可能抑制HDP。
（Docofsoul 译于 2005年5月5日）
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Enzyme could be malaria's weakest link
04 May 2008
NewScientist.com news service
酶可能是疟原虫最薄弱的环节
Malaria parasites kill a million people a year, by
infecting their red blood cells and gobbling up the
haemoglobin proteins that transport oxygen in the
blood.
疟原虫通过感染人体内的红血球以及吞噬血中
输氧的血红蛋白，每年杀死的人数达到一百万。
But the "haem" portion of haemoglobin is toxic and,
to avoid destruction, the Plasmodium parasite turns it
into a non-toxic crystal called haemozoin.
但是血红蛋白中“血红素”部分是有毒的，于是，
为避免殃及自身，疟原虫念起了紧箍咒，让血红
素变成了无毒的称之为疟原虫色素的晶体。
Several existing malaria drugs work by binding to haem
and stopping its transformation. However,
understanding the process better could lead to the
development of desperately needed new drugs for
malaria.
几种现有的抗疟药通过与血红素结合而阻止血红
素变化来发挥作用。不过，更好地理解这一过程
可以引导我们开发急需的抗疟新药。
Now Dewal Jani and his colleagues at Virginia Tech in
Blacksburg have identified the key enzyme used by the
parasite - called HDP. Mass screening has also
identified several chemicals that might inhibit HDP,
which is conserved across all Plasmodium species they
tested.
目前，位于布莱克斯堡的弗尼尼亚工学院的铥
瓦尔· 杰尼与其同事已经证实了疟原虫所用的叫做
HDP的关键的酶，并且所有种类疟原虫体内都贮存有HDP，而大量的筛选工作证明了几种化学品可能抑制HDP。
（Docofsoul 译于 2005年5月5日）
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作者:admin@医学,生命科学 2010-10-08 17:11
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