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【medical-news】非酒精性脂肪肝越严重心肺适应性
Hepatology
Research News Alert
Wiley-Blackwell
March 24, 2008
Study Finds Certain Liver Disease Related to Cardiovascular Fitness Lifestyle Interventions May Help Slow Disease Progression
Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, body composition and physical fitness, according to a new study. The findings appear in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).
About one-in-four U.S. adults suffers from NAFLD, which describes a range of liver disease characterized by excessive fat in the liver. NAFLD is the most common cause of abnormal liver enzymes, and the leading reason for referrals to hepatology clinics. It is considered by many to be a manifestation of the metabolic syndrome which is less prevalent among physically fit people, but little is known about the relationship between fitness and NAFLD severity.
To address this question, researchers led by Joanne Krasnoff of the University of California San Francisco recruited 37 adult patients with a spectrum of NAFLD severity as measured by liver biopsy. Across the spectrum of NAFLD severity, patients had suboptimal cardiorespiratory fitness, muscle strength, body composition and physical activity participation. More than 97 percent had a body fat percentage that put them at increased risk for morbidity and mortality and less than 20 percent currently met recommended guidelines for physical activity.
The study did demonstrate lower cardiorespiratory fitness in subjects with increasing NAFLD severity. “This provocative finding raised the question of a cause-or-effect phenomenon—does cardiorespiratory fitness attenuate NAFLD or does increasing NAFLD severity result in a decline in cardiorespiratory fitness?” the authors ask.
“Despite our study limitations,” the authors conclude, “we believe the objective demonstration of low cardiorespiratory fitness and muscle strength with a high incidence of obesity illustrates the potential clinical relevance of these measures both before and after interventions.” Moreover, the finding that specific measures of NAFLD severity may be associated with cardiorespiratory fitness and past physical activity raises the possibility of a defined therapeutic role for prevention and exercise intervention.
Future studies should include a randomized controlled trial of exercise training that can reveal its direct effects on NAFLD histopathology, they suggest. “In the meantime, it would appear rational and prudent for healthcare providers to recommend exercise training to improve health-related fitness as an integral role in the care of patients with NAFLD,” they conclude. This work was conducted as an ancillary study of the NAFLD Clinical Research Network, a national research consortium funded by the National Institutes of Health.
http://www.blackwellpublishing.com/press/pressitem.asp?ref=1653 本人认领，若48小时内未给出译文，则由其它战友自由认领。 Study Finds Certain Liver Disease Related to Cardiovascular Fitness
研究发现特定的肝病与心血管顺应性相关
Hepatology 肝脏病学
Research News Alert 敏锐的研究消息
Wiley-Blackwell Wiley-Blackwell
March 24, 2008 2008年3月24日
Study Finds Certain Liver Disease Related to Cardiovascular Fitness Lifestyle Interventions May Help Slow Disease Progression
研究发现特定的肝病与心血管顺应性相关，干涉生活方式可以帮助减慢疾病进程。
Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, body composition and physical fitness, according to a new study. The findings appear in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).
根据一项新的研究显示，非酒精性脂肪肝(NAFLD)患者的心血管顺应性，肌力，机体组成和体能都低于最适水平。这一发现刊登在美国肝病研究协会(AASLD)的杂志《肝脏病学》四月刊。文章在Wiley Interscience网站上也有在线提供(www.interscience.wiley.com)。
About one-in-four U.S. adults suffers from NAFLD, which describes a range of liver disease characterized by excessive fat in the liver. NAFLD is the most common cause of abnormal liver enzymes, and the leading reason for referrals to hepatology clinics. It is considered by many to be a manifestation of the metabolic syndrome which is less prevalent among physically fit people, but little is known about the relationship between fitness and NAFLD severity.
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作者:admin@医学,生命科学 2010-12-10 17:11
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