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【medical-news】瑞典科学家发现动脉粥样硬化保护
Article Date: 16 Mar 2008 - 5:00 PDT
Myocardial infarction and stroke cause nearly half of all deaths in the Western World, and atherosclerosis is the main cause of myocardial infarction and stroke. Scientists from the Karolinska Institutet, Sweden, have shown with mouse models that the accumulation of the plaque that causes myocardial infarction and stroke can be avoided.
You can read about this in the March 14th issue of PLoS Genetic.
The authors write about prevention through reducing levels of bad LDL cholesterol before atherosclerotic plaque has progressed beyond a particular point. A network of 37 genes that reduce levels of blood cholesterol to bring about the beneficial effect has also been identified.
Team leader Johan Björkegren, explained "Previously, much atherosclerosis research was focused on identifying ways to stabilise the most dangerous plaques in order to prevent them rupturing and causing myocardial infarction or stroke. Our discovery means that we can now target the actual development of dangerous plaques. The time when individual genes or gene pathways were thought to explain the development of complex common diseases, such as atherosclerosis, is past. We now have enough tools and knowledge of systems biology to take on the total complexity of these diseases."
The findings indicate that atherosclerosis development does not follow a linear progression, but rather first develops slowly without severe inflammation, then speeds up, and within 10 weeks forms advanced plaques. Bringing down plasma cholesterol just before the rapid expansion can prevent the formation of advanced plaques, says Björkegren. The authors took this information and determined 37 of the atherosclerosis genes that respond to the lowering of plasma LDL and prevent the formation of advanced plaques.
The study offers a comprehensive compendium of gene expression profiles of atherosclerosis development from healthy arteries to arteries with advanced plaques. Björkegren admits there must be more than 37 genes in this network, and thus future studies can focus on adding to this group. Björkegren adds that researchers also need to take these identified genes and use model systems in relevant cell cultures and animal model systems to determine their exact biological roles on atherogenesis.
http://www.medicalnewstoday.com/articles/100819.php 认领此篇，48小时完成！ The Genes That Protect Against Atherosclerosis, A Major Cause Of Myocardial Infarction And Stroke
动脉粥样硬化保护基因，心肌梗塞和中风的主要原因
Myocardial infarction and stroke cause nearly half of all deaths in the Western World, and atherosclerosis is the main cause of myocardial infarction and stroke. Scientists from the Karolinska Institutet, Sweden, have shown with mouse models that the accumulation of the plaque that causes myocardial infarction and stroke can be avoided.
在西方世界，心肌梗塞和中风几乎占所有死亡的一半，动脉粥样硬化是心肌梗塞和中风的主要原因。来自瑞典Karolinska研究所的科学家们已经用小鼠模型展示了导致心肌梗塞和中风的斑点积聚是能避免的。
You can read about this in the March 14th issue of PLoS Genetic
在3月14日的PLoS Genetic杂志上你能读到关于这方面的文章。
The authors write about prevention through reducing levels of bad LDL cholesterol before atherosclerotic plaque has progressed beyond a particular point. A network of 37 genes that reduce levels of blood cholesterol to bring about the beneficial effect has also been identified.
作者写道，在动脉粥样硬化斑块进展超过一个特殊的点以前，通过降低有害的低密度脂蛋白胆固醇水平能起到预防作用。一个由37个能降低血胆固醇水平产生有益效应的基因组成的网络系统也被证实。
Team leader Johan Björkegren, explained "Previously, much atherosclerosis research was focused on identifying ways to stabilise the most dangerous plaques in order to prevent them rupturing and causing myocardial infarction or stroke. Our discovery means that we can now target the actual development of dangerous plaques. The time when individual genes or gene pathways were thought to explain the development of complex common diseases, such as atherosclerosis, is past. We now have enough tools and knowledge of systems biology to take on the total complexity of these diseases."
团队领导Johan Björkegren解释道，“以前，许多动脉粥样硬化研究集中在稳定最危险的斑块鉴别方法上，以防止它们破裂和导致心肌梗塞或者中风。我们的发现意味着现在我们能对准危险斑块实际的发展。单基因或基因途径解释复杂常见病如动脉粥样硬化的时代已经过去。现在我们有足够的工具和系统生物学知识来揭示这些疾病完全的复杂性。”
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作者:admin@医学,生命科学 2010-11-25 17:11
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