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【medical-news】【动态版】如何更长寿和更快乐
ScienceDaily (Aug. 21, 2009) — A new study from the University of Missouri may shed light on how to increase the level and quality of activity in the elderly. In the study, published in this week's edition of Public Library of Science – One, MU researchers found that gene therapy with a proven "longevity" gene energized mice during exercise, and might be applicable to humans in the future.
Aging is one of the biggest challenges to a modern society. A pressing issue in the elderly is the loss of activity. What one really wants is not a simple lifespan prolongation but rather a health span increase," said Dongsheng Duan, an associate professor of molecular microbiology and immunology. "After gene therapy with a 'longevity' gene, we studied how well the mice performed on treadmill exercises. We found that the gene therapy worked well and the mice functioned better after the treatment."
Earlier studies have found that mice would live longer when their genome was altered to carry a gene known as mitochondria-targeted catalase gene, or MCAT. However, such approaches would not be applicable to human. Duan and Dejia Li, a post-doctoral researcher working with Duan, took a different approach and placed the MCAT gene inside a benign virus and injected the virus into the mice.
Once injected, Duan and Li tested the mice and found that they could run farther, faster and longer than mice of the same age and sex. Duan attributes this performance enhancement to the MCAT and believes the gene is responsible for removing toxic substances, known as free radicals, from the mitochondria, the powerhouse of the cell. By using this specific gene therapy vector, the virus, to introduce the longevity gene, Duan and Li opened the possibility of human treatment.
"Our results suggest similar therapy may one day improve the life quality of the elderly" Duan said. "This could have important implications for many diseases, such as muscular dystrophy, heart disease, diabetes and neurodegenerative diseases. These patients typically have too many toxic free radicals in their cells."
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更长寿，更快乐
ScienceDaily (Aug. 21, 2009) — A new study from the University of Missouri may shed light on how to increase the level and quality of activity in the elderly. In the study, published in this week's edition of Public Library of Science – One, MU researchers found that gene therapy with a proven "longevity" gene energized mice during exercise, and might be applicable to humans in the future.
每日科学（2009，8，21）--来自密苏里大学的一项研究可能可用于阐明如何提高晚年活动的水平与质量。本研究发表于本周的《公众科学图书馆》（Public Library of Science），一位MU的研究者发现利用被证实的“长寿”基因的基因疗法，可在练习中使小鼠精力充沛。并在将来，这种技术可能可被应用于人类。
Aging is one of the biggest challenges to a modern society. A pressing issue in the elderly is the loss of activity. What one really wants is not a simple lifespan prolongation but rather a health span increase," said Dongsheng Duan, an associate professor of molecular microbiology and immunology. "After gene therapy with a 'longevity' gene, we studied how well the mice performed on treadmill exercises. We found that the gene therapy worked well and the mice functioned better after the treatment."
对现代社会而言，老龄化是一项巨大的挑战。老年最主要的问题就是活动力丧失。人们想要的不仅仅是简单的寿命的延长，他们更希望健康年龄段有所增加”分子微生物学以及免疫学的副教授Dong sheng Duan如是说。“利用‘长寿’基因治疗后，我们研究了小鼠在骑车练习中的表现情况。我们发现，那些接受基因治疗的能进行更好的锻炼，并且在治疗后，小鼠的功能变得更好。”
Earlier studies have found that mice would live longer when their genome was altered to carry a gene known as mitochondria-targeted catalase gene, or MCAT. However, such approaches would not be applicable to human. Duan and Dejia Li, a post-doctoral researcher working with Duan, took a different approach and placed the MCAT gene inside a benign virus and injected the virus into the mice.
早先研究发现，当改变小鼠的基因组使它们携带一种已知的线粒体靶位催化基因（mitochondria-targeted catalase gene, MCAT）时，小鼠的寿命更长。但是，这类方法不能应用于人类。Duan 和在其实验室工作的博士后Dejia Li利用不同的方法将MCAT基因置入一种良性病毒，并将该病毒注射入小鼠体内。
Once injected, Duan and Li tested the mice and found that they could run farther, faster and longer than mice of the same age and sex. Duan attributes this performance enhancement to the MCAT and believes the gene is responsible for removing toxic substances, known as free radicals, from the mitochondria, the powerhouse of the cell. By using this specific gene therapy vector, the virus, to introduce the longevity gene, Duan and Li opened the possibility of human treatment.
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作者:admin@医学,生命科学 2010-10-14 17:11
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