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【medical-news】摄入饮食中α生育酚减少患肺癌的风
NEW YORK (Reuters Health) Sept 01 - A comparison of the effects of various forms of dietary vitamin E on lung cancer risk shows a strong independent relationship only for alpha-tocopherol, researchers report.
The investigators, headed by Dr. Somdat Mahabir at The University of Texas M.D. Anderson Cancer Center in Houston, analyzed the associations between four dietary tocopherols (alpha, beta, gamma, and delta) and lung cancer risk, in a study of 1,088 patients with lung cancer and 1,414 healthy control subjects.
In the September issue of the International Journal of Cancer, the authors explain that dietary data were collected using a modified version of a 135-item questionnaire developed by the National Cancer Institute and administered by trained interviewers. The authors note that only individuals with "reasonable" daily caloric intakes were included.
The researchers constructed two different models for analyzing risk. In the first model, "When dietary intakes of alpha-, beta-, gamma-, and delta-tocopherol were analyzed separately, increasing intakes of alpha-, beta-, and gamma-tocopherol but not delta-tocopherol, were associated with a lower risk of lung cancer," the authors report.
Specifically, with increasing quartiles of intake, the odds ratios for lung cancer were 0.63, 0.58, and 0.39 with alpha-tocopherol; 0.79, 0.59, and 0.56 with beta-tocopherol; and 0.84, 0.76, and 0.56 with gamma-tocopherol.
"In model 2, for which the association of a specific tocopherol was adjusted for all the other tocopherols, only the alpha-tocopherol association remained significant," the investigators write. The odds ratios with increasing quartiles of intake were 0.66, 0.64, and 0.47.
They add that in model 1, the protective effect of alpha-tocopherol did not depend on subjects' smoking status. In model 2, however, the inverse relationship remained significant only among current or former smokers, with "a more pronounced risk reduction seen in current smokers."
"To the best of our knowledge, this is the first study to compare dietary intakes of the different forms of tocopherols and lung cancer risk," the researchers write.
They acknowledge that estimates of dietary tocopherol intake are very difficult to assess and that their case-control study had multiple limitations. Still, they conclude, "Our data should be useful in stimulating additional epidemiologic and basic science research in the relationship of different forms of vitamin E and cancer."
Int J Cancer 2008;123:1173-1180.
摄入饮食中α生育酚减少患肺癌的风险
纽约(路透健康通讯社)9.1 –研究报道，比较饮食中不同形式vit E对患肺癌危险的影响表明仅α生育酚呈现强烈的独立相关性.
由Texas大学 M.D. Anderson与休斯顿癌症中心Dr. Somdat Mahabir领导的研究小组，对1,088个肺癌病人与1,414 个健康对照受试者进行了一项研究，旨在分析食物中四种生育酚(alpha, beta, gamma, and delta)与肺癌危险的相关性。
作者在国际癌症杂志第9期中指出，饮食资料的收集由受过专门训练的调查员按国立癌症研究所制定的135项问卷调查表的修改版本负责完成，研究人群仅纳入日常热量摄入"合理"的受试者.
研究者制作了两个不同危险分析模型，使用第一个分析模型, "当单独分析饮食中α、β、γ、δ-生育酚摄入情况, 发现α、β、γ-生育酚摄入增加与肺癌低风险有关，而δ-生育酚不存在这种相关性,"
特别是, 摄入四分位数增加, 肺癌优势比分别为：α生育酚（0.63, 0.58, 0.39）；β-生育酚（0.79, 0.59, 0.56）; γ－生育酚（0.84, 0.76, 0.56）
"在模型2中, 修正特异生育酚与其他生育酚的相关性后，仅α生育酚的相关性仍然显著," 研究者著述， 随摄入四分位数增加优势比为0.66, 0.64, 0.47.
他们进一步补充道，在模型1中,α生育酚保护效应不依赖受试者的吸烟状况；然而，在模型2中, 仅现时或既往吸烟者负相关性仍然显著，"特别在现时吸烟者风险减小更显著."
"据我们所知, 此为比较饮食中不同形式生育酚摄取与肺癌危险性关系的首次研究,"
他们承认分析估计饮食生育酚摄入非常困难，其病例对照研究具有诸多局限性；尽管如此，他们仍然认为, "我们的资料对激励不同形式vitamin E和癌症关系的流行病学及基础研究具有非常重要作用"
Int J Cancer 2008;123:1173-1180.
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作者:admin@医学,生命科学 2010-10-08 05:11
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