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【medical-news】血压在患有1型糖尿病的青少年视网
Objective To examine the relation between blood pressure and the development of early retinopathy in adolescents with childhood onset type 1 diabetes.
Design Prospective cohort study.
Setting Diabetes Complications Assessment Service at the Children’s Hospital at Westmead, Sydney, Australia.
Participants 1869 patients with type 1 diabetes (54% female) screened for retinopathy with baseline median age 13.4 (interquartile range 12.0-15.2) years, duration 4.9 (3.1-7.0) years, and albumin excretion rate of 4.4 (3.1-6.8) µg/min plus a subgroup of 1093 patients retinopathy-free at baseline and followed for a median 4.1 (2.4-6.6) years.
Main outcome measures Early background retinopathy; blood pressure.
Results Overall, retinopathy developed in 673 (36%) participants at any time point. In the retinopathy-free group, higher systolic blood pressure (odds ratio 1.01, 95% confidence interval 1.003 to 1.02) and diastolic blood pressure (1.01, 1.002 to 1.03) were predictors of retinopathy, after adjustment for albumin excretion rate (1.27, 1.13 to 1.42), haemoglobin A1c (1.08, 1.02 to 1.15), duration of diabetes (1.16, 1.13 to 1.19), age (1.13, 1.08 to 1.17), and height (0.98, 0.97 to 0.99). In a subgroup of 1025 patients with albumin excretion rate below 7.5 µg/min, the cumulative risk of retinopathy at 10 years’ duration of diabetes was higher for those with systolic blood pressure on or above the 90th centile compared with those below the 90th centile (58% v 35%, P=0.03). The risk was also higher for patients with diastolic blood pressure on or above the 90th centile compared with those below the 90th centile (57% v 35%, P=0.005).
Conclusions Both systolic and diastolic blood pressure are predictors of retinopathy and increase the probability of early retinopathy independently of incipient nephropathy in young patients with type 1 diabetes. Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study
Objective To examine the relation between blood pressure and the development of early retinopathy in adolescents with childhood onset type 1 diabetes.
Design Prospective cohort study.
Setting Diabetes Complications Assessment Service at the Children’s Hospital at Westmead, Sydney, Australia.
血压在1型糖尿病青少年患者视网膜病变发展中的作用：前瞻性队列研究。
为了研究血压在1型糖尿病青少年患者视网膜病变发展中的作用，设计前瞻性研究。在澳大利亚悉尼西部的mead儿童医院建立评估中心。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study
题目：一项关于血压在患有1型糖尿病的青少年早期视网膜病发展中的角色的前瞻性队列研究
Objective To examine the relation between blood pressure and the development of early retinopathy in adolescents with childhood onset type 1 diabetes.
实验目的：为了调查血压同童年开始患有1型糖尿病的青少年早期视网膜病发展的相关性。
Design Prospective cohort study.
实验设计：前瞻性队列研究
Setting Diabetes Complications Assessment Service at the Children’s Hospital at Westmead, Sydney, Australia.
在澳大利亚悉尼Westmead的儿童医院设置了糖尿病并发症评价服务。
Participants 1869 patients with type 1 diabetes (54% female) screened for retinopathy with baseline median age 13.4 (interquartile range 12.0-15.2) years, duration 4.9 (3.1-7.0) years, and albumin excretion rate of 4.4 (3.1-6.8) µg/min plus a subgroup of 1093 patients retinopathy-free at baseline and followed for a median 4.1 (2.4-6.6) years.
参与的1869名患有1型糖尿病的病人（54%是女性）经筛检患有视网膜病。基线资料为，中位数年龄为13.4岁，年龄的四分位数间距为12.0岁——15.2岁，患病时间中位数为4.9(3.1-7.0)年，并且白蛋白清除率为4.4（3.1—6.8）ug/min。对照组是由1093名没有患视网膜病的1型糖尿病病人组成，他们患病时间中位数为4.1 (2.4-6.6)年。
Main outcome measures Early background retinopathy; blood pressure.
主要结局指标是测量早期的基础视网膜病和血压。
Results Overall, retinopathy developed in 673 (36%) participants at any time point. In the retinopathy-free group, higher systolic blood pressure (odds ratio 1.01, 95% confidence interval 1.003 to 1.02) and diastolic blood pressure (1.01, 1.002 to 1.03) were predictors of retinopathy, after adjustment for albumin excretion rate (1.27, 1.13 to 1.42), haemoglobin A1c (1.08, 1.02 to 1.15), duration of diabetes (1.16, 1.13 to 1.19), age (1.13, 1.08 to 1.17), and height (0.98, 0.97 to 0.99).
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作者:admin@医学,生命科学 2010-10-07 17:11
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