主页 > 生命科学 >
【文摘发布】临床前期犬同种肾移植模型获得长
Author：Kuhr, Christian S， Yunusov, Murad ， Sale, George ，et al.
Source：Transplantation. 84(4):545-547, August 27, 2007.
Abstract：Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression. Subsequently, donor renal allografts were transplanted accompanied by bilateral native nephrectomies. With 5-year follow up, we found normal renal function in all recipients and no histological evidence of acute or chronic rejection. This tolerance does not extend universally to donor skin grafts, however, with two of four animals rejecting delayed donor skin grafts. Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting. Title：Long-Term Tolerance to Kidney Allografts in a Preclinical Canine Model
临床前期犬同种肾移植模型获得长期免疫耐受
Author：Kuhr, Christian S， Yunusov, Murad ， Sale, George ，et al.
作者：Kuhr, Christian S， Yunusov, Murad ， Sale, George ，et al
Source：Transplantation. 84(4):545-547, August 27, 2007.
来源：移植， 84(4):545-547, August 27, 2007.
Abstract：Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression. Immune tolerance to renal allografts was induced in a preclinical canine model through engraftment of donor hematopoietic cells using a combination of low-dose total body irradiation and a short course of immunosuppression.
通过给前期临床试验的犬模型植入供者造血干细胞，联合低剂量全身照射和短期免疫抑制，诱发肾移植免疫耐受。
Subsequently, donor renal allografts were transplanted accompanied by bilateral native nephrectomies：然后，受者体内植入供肾，自体双侧肾脏切除。
This tolerance does not extend universally to donor skin grafts, however, with two of four animals rejecting delayed donor skin grafts. 但肾脏的耐受在供者的皮肤移植中并不普遍存在，2/4的试验动物对随后的供者皮肤移植物产生了排斥。 [标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-08-24 05:11
医学,生命科学网