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【medical-news】抗生素耐药细菌靶位蛋白的发现
2/14/2007
Source: Queen's University
Model could be used in new treatments for food poisoning, typhoid
A new type of protein discovered by Queen’s University researchers may be useful in developing treatments for antibiotic-resistant bacteria, such as those that cause food poisoning and typhoid.
By solving the structure and activity of the protein – called YihE or RdoA – a team of professors and students from the departments of Biochemistry and Microbiology & Immunology has opened up possibilities for new drug development.
“Our group is the first to solve the structure and to begin to understand the function of this particular protein,” says Dr. Nancy Martin (Microbiology & Immunology), who coordinated the study with Dr. Zongchao Jia (Biochemistry). “It turns out to be a potentially good target in a wide range of bacteria that cause infectious diseases.” Because of the increasing number of antibiotic-resistant strains of many different types of bacteria, such as salmonella, she notes, new approaches to antibiotic therapy are needed.
The Queen’s findings are published in the on-line edition of the journal Molecular Microbiology. Also on the team, from Biochemistry, are PhD student Jimin Zheng and post-doctoral fellow Vinay Singh; and Microbiology & Immunology Master’s student Chunhua He.
The group is studying sensory pathways used by bacteria that enter our bodies and move from the stomach into the gastro-intestinal tract. “If we can block the sensory pathway, then the bacteria can’t adapt to that change in their environment, and won’t be able to infect,” says Dr. Martin.
In North America, the people treated for food poisoning with drugs tend to be elderly or “immune compromised” where there is a need for antibiotics to clear the infection. Since the organism that causes salmonellosis is related to that responsible for typhoid fever – a huge problem in less developed countries – the model being developed at Queen’s could potentially be a target for treating typhoid as well. The underlying goal is to control, if not clear, the infection.
“It’s basic science that we are doing, but we’re using that as a foundation for trying to develop approaches that will have positive impacts on human health,” says Dr. Martin.
## 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Protein Discovery Targets Antibiotic-Resistant Bacteria
2/14/2007
抗生素耐药细菌靶蛋白发现
Source: Queen's University
来源：女王大学
Model could be used in new treatments for food poisoning, typhoid
在治疗食物中毒，伤寒的新方法中已可使用模型。
A new type of protein discovered by Queen’s University researchers may be useful in developing treatments for antibiotic-resistant bacteria, such as those that cause food poisoning and typhoid.
由女王大学研究人员发现的一种新型蛋白在耐抗生素细菌治疗方法开发中可能起作用，如引起食物中毒或伤寒的细菌。
By solving the structure and activity of the protein – called YihE or RdoA – a team of professors and students from the departments of Biochemistry and Microbiology & Immunology has opened up possibilities for new drug development.
通过研究称做YihE或RdoA的蛋白的结构和活性，一个来自生物化学，微生物学和免疫学的由教授和学生组成的小组为新药的开发提供了可能性。
“Our group is the first to solve the structure and to begin to understand the function of this particular protein,” says Dr. Nancy Martin (Microbiology & Immunology), who coordinated the study with Dr. Zongchao Jia (Biochemistry). “It turns out to be a potentially good target in a wide range of bacteria that cause infectious diseases.” Because of the increasing number of antibiotic-resistant strains of many different types of bacteria, such as salmonella, she notes, new approaches to antibiotic therapy are needed.
与Zongchao Jia 博士（生物化学）合作进行这项研究的Nancy Martin博士（微生物学和免疫学）说：“我们小组第一个解决了其结构并开始理解这种蛋白的功能。结果发现它是大量引起传染性疾病细菌的一个潜在的好靶点。”她还说由于很多不同种类细菌的耐药菌种数量增多，如沙门氏菌，我们需要新的抗生素治疗方法。
The Queen’s findings are published in the on-line edition of the journal Molecular Microbiology. Also on the team, from Biochemistry, are PhD student Jimin Zheng and post-doctoral fellow Vinay Singh; and Microbiology & Immunology Master’s student Chunhua He.
女王学院的发现在《分子微生物学》杂志的一个在线刊物上发表。这个小组还包括，生物化学方面的PhD研究生Jimin Zheng和博士后Vinay Singh同志，微生物学和免疫学硕士学生Chunhua He
The group is studying sensory pathways used by bacteria that enter our bodies and move from the stomach into the gastro-intestinal tract. “If we can block the sensory pathway, then the bacteria can’t adapt to that change in their environment, and won’t be able to infect,” says Dr. Martin.
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作者:admin@医学,生命科学 2011-07-21 01:08
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